Symbol
Name
ID

Shh
sonic hedgehog
MGI:98297

Phenotype annotations related to respiratory system

Darker colors indicate more annotations

Human Phenotypes	Abnormal nasopharynx morphology	Aplasia/Hypoplasia of the lungs	Respiratory insufficiency
Disease(s) Associated with SHH	Abnormal nasopharynx morphology	Aplasia/Hypoplasia of the lungs	Respiratory insufficiency
holoprosencephaly
solitary median maxillary central incisor

Mouse Phenotypes

abnormal lung vasculature morphology

abnormal nasal bone morphology

abnormal nasal pit morphology

tracheoesophageal fistula

lung cyst

abnormal tracheal smooth muscle morphology

abnormal respiratory system morphology

abnormal lung morphology

abnormal lung development

abnormal branching involved in lung morphogenesis

impaired branching involved in bronchus morphogenesis

abnormal lung saccule morphology

impaired lung lobe morphogenesis

pulmonary hypoplasia

abnormal respiratory conducting tube morphology

abnormal bronchus morphology

abnormal pharynx morphology

abnormal trachea morphology

abnormal tracheal cartilage morphology

decreased tracheal cartilage ring number

absent tracheal cartilage rings

Availability

Mouse Genotype

Shh^{tm1(EGFP/cre)Cjt}/Shh^{tm1(EGFP/cre)Cjt}

Shh^tm1Amc/Shh^tm1Amc

Shh^tm1Chg/Shh^tm1Chg

Shh^tm3(cre)Chg/Shh^tm3(cre)Chg

Shh^tm2Amc/Shh^tm2Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Shh^tm1Amc/Shh^tm2Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Shh^tm1Amc/Shh^tm2Amc
Tg(KRT14-cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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